From Complexity to Clarity.
We connect complex clinical evidence and methods with the questions that matter for health technology assessment and reimbursement decisions. Our senior experts deliver rigorous evidence synthesis, indirect treatment comparisons and strategic guidance.
Synthesis
Systematic and targeted literature reviews
Strategy
Evidence planning, including EU JCA
Comparison
Indirect treatment comparisons
Support at every stage of evidence generation and synthesis
Evidence identification & feasibility
Structure the evidence base, assess feasibility and define key assumptions before committing to an analytical approach.
Learn more →Analytical design & execution
NMA, MAIC, STC, ML-NMR, external control, crossover adjustment, surrogacy and survival modelling.
Learn more →Regulatory & HTA submission support
Technical reports and reviewer responses aligned with NICE, JCA, CDA-AMC and other HTA bodies.
Learn more →Strategic methods & training
Estimand and trial design input, evidence strategy and bespoke comparative effectiveness training.
Learn more →AI-enabled evidence synthesis
AI tools for screening, extraction and feasibility, with expert oversight and documented QA.
Learn more →unpuzzle /ʌnˈpʌzəl/ verb
To make sense of something complex by connecting its parts, revealing patterns, and bringing insights.
Founder-led, start to finish
The people who scope the work are the people who do it. No hand-off to junior staff after contract signature.
HTA-aligned from the start
We know what reviewers look for and document assumptions transparently enough to withstand scrutiny.
AI-enabled, not AI-dependent
We use AI to move faster, always with expert oversight, transparent methods and documented QA.
Heather Burnett
Shannon Cope
Sarah GoringReady to solve your evidence challenge?
Tell us about your evidence question. Based in Canada, working globally.